Elements DNA
Published research · Hormone

Sermorelin

Synthetic 29-amino-acid GHRH analogue studied at the pituitary GHRH receptor

8 papers · 1986–2026 · 8 journals

What the research explores

Sermorelin appears in the literature primarily as a reference agonist for the GHRH receptor, a class B GPCR expressed on pituitary somatotrophs. Research topics include:

  • Receptor binding affinity and cAMP signalling in somatotroph cell models
  • Pulsatile versus continuous receptor stimulation and the resulting secretory patterns in animal models
  • Comparison against longer-acting GHRH analogues to isolate the contribution of half-life to signalling
  • Enzymatic degradation by dipeptidyl peptidase-4 and strategies for stabilising the N-terminus

Each item above describes an area of published investigation. None is a statement of benefit. Elements DNA supplies this peptide for in vitro and preclinical laboratory work only.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2026

    1. A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review

      Coutinho LFD, DE Oliveira Neves LF, Camilo RP

      The Journal of sports medicine and physical fitness

      PMID 41880199doi 10.23736/S0022-4707.26.17773-1

  2. 2023

    1. Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis

      Otin J, Tran NT, Benoit A, et al.

      Electrophoresis

      PMID 36787346doi 10.1002/elps.202200278

    2. Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples

      Cristea CD, Radu M, Toboc A, et al.

      Analytical biochemistry

      PMID 37806509doi 10.1016/j.ab.2023.115336

    3. In-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides

      González-López NM, Guerra-Acero-Turizo LM, Blanco-Medina I, et al.

      Biomedical chromatography : BMC

      PMID 37688464doi 10.1002/bmc.5741

  3. 2021

    1. Advances in the detection of growth hormone releasing hormone synthetic analogs

      Memdouh S, Gavrilović I, Ng K, et al.

      Drug testing and analysis

      PMID 34665524doi 10.1002/dta.3183

  4. 2003

    1. PEGylation of growth hormone-releasing hormone (GRF) analogues

      Esposito P, Barbero L, Caccia P, et al.

      Advanced drug delivery reviews

      PMID 14499707doi 10.1016/s0169-409x(03)00109-1

  5. 1997

    1. When the light turns blue

      Barkan A

      Endocrinology

      PMID 9348173doi 10.1210/endo.138.11.5646

  6. 1986

    1. Growth hormone releasing hormone

      Grossman A, Savage MO, Besser GM

      Clinics in endocrinology and metabolism

      PMID 2429796doi 10.1016/s0300-595x(86)80012-3

More research in hormone

For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA