Elements DNA
Published research · Hormone

Ipamorelin

Synthetic pentapeptide studied as a selective ghrelin receptor (GHS-R1a) agonist

7 papers · 1998–2026 · 5 journals

What the research explores

Ipamorelin is frequently used as a selectivity control in secretagogue pharmacology. Published research explores:

  • Binding affinity and functional potency at GHS-R1a relative to other secretagogues
  • Selectivity profiling against receptors implicated in off-target signalling by earlier compounds
  • Calcium mobilisation and inositol phosphate readouts in receptor-expressing cell lines
  • Comparative studies pairing GHS-R1a agonism with GHRH receptor agonism in animal models
  • Structure-activity work on how the pentapeptide scaffold tolerates substitution

Each of these is an area of scientific investigation described in the literature, not a claim of effect. Elements DNA supplies this compound for in vitro and preclinical laboratory research only.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2026

    1. A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review

      Coutinho LFD, DE Oliveira Neves LF, Camilo RP

      The Journal of sports medicine and physical fitness

      PMID 41880199doi 10.23736/S0022-4707.26.17773-1

  2. 2024

    1. The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus

      Gouda M, Ganesh CB

      Animal reproduction science

      PMID 38996787doi 10.1016/j.anireprosci.2024.107550

  3. 2020

    1. Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics

      N Mohammadi E, Louwies T, Pietra C, et al.

      Journal of experimental pharmacology

      PMID 32801950doi 10.2147/JEP.S249747

  4. 2018

    1. Analysis of new growth promoting black market products

      Krug O, Thomas A, Malerød-Fjeld H, et al.

      Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

      PMID 29864719doi 10.1016/j.ghir.2018.05.001

  5. 2001

    1. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats

      Andersen NB, Malmlöf K, Johansen PB, et al.

      Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

      PMID 11735244doi 10.1054/ghir.2001.0239

  6. 1999

    1. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats

      Johansen PB, Nowak J, Skjaerbaek C, et al.

      Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

      PMID 10373343doi 10.1054/ghir.1999.9998

  7. 1998

    1. Ipamorelin, the first selective growth hormone secretagogue

      Raun K, Hansen BS, Johansen NL, et al.

      European journal of endocrinology

      PMID 9849822doi 10.1530/eje.0.1390552

More research in hormone

For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA