IGF1-LR3
83-residue IGF-1 analog, 1 mg lyophilized vial
8 papers · 2001–2025 · 7 journals
What the research explores
The analog exists to answer a methodological problem, and most of its literature reflects that. Areas of study include:
- IGFBP interaction — comparative binding of the modified and native sequences to the six IGF binding proteins.
- IGF-1 receptor engagement and downstream PI3K/Akt and MAPK signaling in cell culture.
- Receptor cross-talk with the insulin receptor and hybrid receptor forms, where selectivity is a persistent question.
- Use as a defined media component in serum-free cell culture, where a binding-protein-resistant growth factor gives more reproducible conditions.
- Protein stability in solution and across freeze-thaw.
Supplied as a laboratory reagent. We make no claim about effects in any organism.
References
A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.
2025
- Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration
Yavuz E, Sağır MS, Ercan A, et al.
International journal of biological macromolecules
- IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep
White A, Stremming J, Wesolowski SR, et al.
American journal of physiology. Endocrinology and metabolism
- Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration
2023
- Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris
Lu Z, Liu N, Huang H, et al.
Applied microbiology and biotechnology
- Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets
White A, Stremming J, Brown LD, et al.
Journal of developmental origins of health and disease
- Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris
2021
- IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus
Stremming J, Heard S, White A, et al.
American journal of physiology. Endocrinology and metabolism
- IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus
2020
- Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep
Jonker SS, Giraud GD, Chang EI, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep
2007
- Effects of IGF-I bioavailability on bovine preantral follicular development in vitro
Thomas FH, Campbell BK, Armstrong DG, et al.
Reproduction (Cambridge, England)
- Effects of IGF-I bioavailability on bovine preantral follicular development in vitro
2001
- Physicochemical characteristics of LR3-IGF1 protein inclusion bodies: electrophoretic mobility studies
Wangsa-Wirawan ND, O'Neill BK, Middelberg AP
Biotechnology progress
- Physicochemical characteristics of LR3-IGF1 protein inclusion bodies: electrophoretic mobility studies
For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA