GHK-Cu Nasal Spray

GHK-Cu is the copper(II) complex of glycyl-L-histidyl-L-lysine, a tripeptide first isolated from human plasma. The copper sits in a square-planar coordination site assembled from the histidine imidazole, the terminal amine and backbone nitrogens — an affinity high enough that the complex, not the free peptide, is the species most of the literature actually studies. The blue colour of the solution comes from that copper centre.

This item ships already in solution: 100 mg of GHK-Cu in a sterile isotonic saline base, filled to 30 ml in a sealed bottle with a metered pump rated at approximately 120 actuations. Copper complexes are light- and oxidation-sensitive, so the bottle stays sealed and cold. Supplied for laboratory research use only.

GHK-Cu is studied primarily as coordination chemistry and as a cell-culture reagent. Reported areas include:

• Copper binding and transfer — stability constants of the complex and exchange with cellular copper ligands such as albumin and metallothionein.
• Matrix protein expression — collagen and glycosaminoglycan synthesis readouts in fibroblast culture.
• Gene-expression profiling in dermal cell models, where the complex is applied as an in vitro test condition.
• Redox chemistry — copper as a cofactor in superoxide dismutase and related enzymes.
• Complex stability in aqueous formulation over time.

These are in vitro and model-system findings. We make no claim about effects in people.