Elements DNA
Published research · Tissue

GHK-Cu

Copper-binding tripeptide, studied in matrix-protein and fibroblast research.

8 papers · 2015–2026 · 8 journals

What the research explores

GHK and its copper complex are studied largely in the context of extracellular matrix biology and copper transport.

Areas examined in the literature:

  • Copper(II) binding, and transport of the ion between plasma proteins and cells
  • Fibroblast behaviour in culture, including collagen and glycosaminoglycan production
  • Expression of matrix metalloproteinases and their tissue inhibitors
  • Gene-expression profiling, where the tripeptide has been reported to shift transcription across a broad set of human genes
  • Dermal and connective-tissue wound models in animals

The work is preclinical and in vitro. GHK-Cu is supplied as a laboratory research material with no approved application in humans.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2026

    1. Smart Healing for Wound Repair: Emerging Multifunctional Strategies in Personalized Regenerative Medicine and Their Relevance to Orthopedics

      Arciola CR, Panichi V, Bua G, et al.

      Antibiotics (Basel, Switzerland)

      PMID 41594073doi 10.3390/antibiotics15010036

  2. 2025

    1. Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective

      Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR

      BioImpacts : BI

      PMID 39963574doi 10.34172/bi.30071

  3. 2024

    1. The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6

      Bian Y, Deng M, Liu J, et al.

      Redox biology

      PMID 38879894doi 10.1016/j.redox.2024.103237

  4. 2023

    1. Phenothiazine-Based Cu(II)-Selective Fluorescent Sensor: GHK-Cu Sensing Applications

      Sahu R, Yadav S, Gunturu KC, et al.

      The Journal of organic chemistry

      PMID 37830186doi 10.1021/acs.joc.3c01600

    2. Glycyl-l-histidyl-l-lysine-Cu(2+) rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway

      Deng M, Zhang Q, Yan L, et al.

      Journal of cachexia, sarcopenia and muscle

      PMID 36905132doi 10.1002/jcsm.13213

  5. 2022

    1. Polyaspartic acid, 2-acrylamido-2-Methyl propane sulfonic acid and sodium alginate based biocompatible stimuli responsive polymer gel for controlled release of GHK-Cu peptide for wound healing

      Sharma S, Anwar MF, Dinda AK, et al.

      Journal of biomaterials applications

      PMID 35341370doi 10.1177/08853282221076708

  6. 2018

    1. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

      Pickart L, Margolina A

      International journal of molecular sciences

      PMID 29986520doi 10.3390/ijms19071987

  7. 2015

    1. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

      Pickart L, Vasquez-Soltero JM, Margolina A

      BioMed research international

      PMID 26236730doi 10.1155/2015/648108

More research in tissue

For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA