Semax
Heptapeptide built on an ACTH fragment, studied in neurotrophic-signalling research.
7 papers · 2014–2025 · 7 journals
What the research explores
Semax is studied within the neuropeptide literature, largely in rodent models and cell culture.
Areas investigators have examined:
- Expression of brain-derived neurotrophic factor and nerve growth factor in rodent hippocampus
- Dopaminergic and serotonergic system activity in animal models
- Gene-expression changes in models of experimental cerebral ischaemia
- Antioxidant and inflammatory markers within those same ischaemia models
- Behavioural endpoints such as maze performance in rodents
Much of the primary work is published in Russian-language journals and has seen limited independent replication elsewhere, which is worth weighing when reading the literature. Semax is supplied for laboratory research only.
References
A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.
2025
- Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice
Liu R, Chen Y, Huang H, et al.
British journal of pharmacology
- Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage
Filippenkov IB, Shpetko YY, Ales DA, et al.
International journal of molecular sciences
- Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice
2024
- ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke
Filippenkov IB, Shpetko YY, Stavchansky VV, et al.
Biomedicines
- ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke
2020
- Functional Connectomic Approach to Studying Selank and Semax Effects
Panikratova YR, Lebedeva IS, Sokolov OY, et al.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
- Functional Connectomic Approach to Studying Selank and Semax Effects
2018
- Pharmacological Aspects of Neuro-Immune Interactions
Tarasov VV, Kudryashov NV, Chubarev VN, et al.
Current pharmaceutical design
- Pharmacological Aspects of Neuro-Immune Interactions
2017
- Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats
Medvedeva EV, Dmitrieva VG, Limborska SA, et al.
Molecular genetics and genomics : MGG
- Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats
2014
- The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
Medvedeva EV, Dmitrieva VG, Povarova OV, et al.
BMC genomics
- The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
More research in cognitive
For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA