Elements DNA
Published research · Cognitive

Pinealon

Short peptide bioregulator (Glu-Asp-Arg), studied in neuronal cell models.

8 papers · 2008–2016 · 3 journals

What the research explores

Pinealon is examined within the short-peptide-bioregulator literature, a body of work that is small and concentrated in a handful of research groups.

Areas of study:

  • Binding interactions with DNA and histone proteins in cell-free systems
  • Neuronal cell survival in culture under experimental oxidative stress
  • Expression of markers associated with programmed cell death in cultured cells
  • Rodent behavioural studies following prenatal hypoxia models

Independent replication outside the originating institutions is limited, and this is best read as an early-stage literature rather than a settled one. Pinealon is supplied strictly as a research material with no approved application in humans.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2016

    1. [Comparative analysis of different methods of geroprotective]

      Myakotnykh VS, Torgashov MN, Egorin KV, et al.

      Advances in gerontology = Uspekhi gerontologii

      PMID 28539017

  2. 2015

    1. [Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia]

      Mendzheritsky AM, Karantysh GV, Ryzhak GA, et al.

      Advances in gerontology = Uspekhi gerontologii

      PMID 28509493

  3. 2013

    1. [Neuroprotective effects of peptides bioregulators in people of various age]

      Umnov RS, Lin'kova NS, Khavinson VKh

      Advances in gerontology = Uspekhi gerontologii

      PMID 24738258

  4. 2012

    1. [Analysis of some parameters of biological age and adaptation possibilities of workers of locomotive brigades]

      Nazimko VA, Morgul' EV, Petrova OA, et al.

      Advances in gerontology = Uspekhi gerontologii

      PMID 22708445

    2. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia

      Arutjunyan A, Kozina L, Stvolinskiy S, et al.

      International journal of clinical and experimental medicine

      PMID 22567179

  5. 2011

    1. [Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats]

      Mendzheritskiĭ AM, Karantysh GV, Ivonina KO

      Advances in gerontology = Uspekhi gerontologii

      PMID 21809624

    2. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA

      Fedoreyeva LI, Kireev II, Khavinson VKh, et al.

      Biochemistry. Biokhimiia

      PMID 22117547doi 10.1134/S0006297911110022

  6. 2008

    1. [Investigation of antihypoxic properties of short peptides]

      Kozina LS

      Advances in gerontology = Uspekhi gerontologii

      PMID 18546825

More research in cognitive

For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA