DihexA
Angiotensin IV analogue, studied in hepatocyte growth factor signalling research.
8 papers · 2005–2024 · 7 journals
What the research explores
DihexA appears in a narrow preclinical literature centred on hepatocyte growth factor and its receptor.
Areas of study:
- Interaction with hepatocyte growth factor and c-Met receptor signalling
- Dendritic spine formation and synaptogenesis in cultured hippocampal neurons
- Rodent cognition models, including water-maze paradigms following experimental cholinergic lesion
- Blood–brain-barrier permeability, a pharmacokinetic property that was a stated design goal
The c-Met pathway is also implicated in tumour biology, and that overlap remains an open question in the literature rather than a resolved one. DihexA is an investigational compound with no approved use in any species and is supplied for laboratory research only.
References
A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.
2024
- Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats
Wells RG, Azzam AF, Hiller AL, et al.
Journal of Huntington's disease
- Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats
2022
- Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy
Pan T, Wang N, Zhang J, et al.
Stem cell research & therapy
- Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy
2018
- Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies
Ho JK, Nation DA
Neuroscience and biobehavioral reviews
- Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies
2016
- Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells
Mathapati S, Siller R, Impellizzeri AA, et al.
Current protocols in stem cell biology
- Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells
2015
- Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure
Uribe PM, Kawas LH, Harding JW, et al.
Frontiers in cellular neuroscience
- Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure
2014
- The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
Benoist CC, Kawas LH, Zhu M, et al.
The Journal of pharmacology and experimental therapeutics
- The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
2013
- Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents
McCoy AT, Benoist CC, Wright JW, et al.
The Journal of pharmacology and experimental therapeutics
- Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents
2005
- Studies on the subcellular localization of the porphycene CPO
Kessel D, Conley M, Vicente MG, et al.
Photochemistry and photobiology
- Studies on the subcellular localization of the porphycene CPO
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For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA