Semax Nasal Spray
ACTH(4-7) fragment analog in a 30 ml metered solution
1 × $60 = $60. Applied in your cart.
- Every batch tested by an independent laboratory — identity by HPLC and mass spec.
- Dispatched on business days once payment has cleared. Free shipping over $100 — flat $10 otherwise.
- Discreet packaging, tracked and insured on every shipment.
For laboratory and research use only · Not for human consumption
- Certificate
- Record in preparation
- Class
- Synthetic heptapeptide (ACTH(4-7) analog)
- Form
- Solution in sterile isotonic saline
What we test, every batch.
Each production lot of Semax Nasal Spray is analysed by an independent laboratory before it ships. Its certificate is not in our published archive yet — we won't link one we don't hold.
Certificates we have publishedThe panel, every batch
- Identity
- HPLC + mass spec
- Purity
- HPLC · figure on the batch COA
- Net peptide content
- HPLC
- Heavy metals
- ICP-MS
- Sterility
- PCR
- Endotoxin
- USP <85>
What it is
Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone: the ACTH(4-7) fragment Met-Glu-His-Phe, extended at the C-terminus with Pro-Gly-Pro. The fragment carries none of the corticotropic activity of the parent hormone, and the added tripeptide tail slows cleavage by aminopeptidases. It is made by solid-phase synthesis.
This item ships as a prepared solution rather than a lyophilized powder — Semax in a sterile isotonic saline base, filled to 30 ml in a sealed bottle with a metered atomizing pump rated at approximately 120 actuations. Peptide content for this format is stated on the batch record rather than on this listing. Supplied for laboratory research use only.
What the research explores
Semax appears in preclinical neuropharmacology literature as a tool compound for fragment-versus-parent-hormone questions. Areas of study include:
- Melanocortin-independent activity — how an ACTH fragment stripped of the receptor-binding region behaves relative to the full hormone.
- Neurotrophin expression, principally BDNF and NGF transcript readouts in rodent brain tissue.
- Monoamine turnover — dopaminergic and serotonergic measurements in animal models.
- Peptidase resistance — degradation kinetics of the Pro-Gly-Pro extension versus the bare tetrapeptide.
These are research areas, not established effects. We make no outcome claim for this compound.
Questions
How should the bottle be stored?
Refrigerated, sealed and away from light. Solutions degrade faster than dry powder, so the cold chain matters more for this format.
Why is the peptide content not printed on the listing?
Because we publish the fill figure from the batch record rather than a catalog estimate. The lot documentation carries the number for the bottle you receive.
What does the Certificate of Analysis cover?
Identity and purity of the batch as determined by the testing lab, tied to the lot on the bottle. It is a characterization document, not a clearance for any use.
What arrives in the box?
One sealed 30 ml bottle with its metered pump, labelled with compound and lot. Research use only.
Literature
7 publications · 2014–2025
Peer-reviewed publications indexed on PubMed that discuss Semax Nasal Spray. Listed for reference only — inclusion is not a claim about this product or its effects.
- 2025Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice
Liu R, Chen Y, Huang H, et al. · British journal of pharmacology
PMID 40692165 · doi 10.1111/bph.70122
- 2025Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage
Filippenkov IB, Shpetko YY, Ales DA, et al. · International journal of molecular sciences
PMID 40650034 · doi 10.3390/ijms26136256
- 2024ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke
Filippenkov IB, Shpetko YY, Stavchansky VV, et al. · Biomedicines
PMID 39767736 · doi 10.3390/biomedicines12122830
- 2020Functional Connectomic Approach to Studying Selank and Semax Effects
Panikratova YR, Lebedeva IS, Sokolov OY, et al. · Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
PMID 32342318 · doi 10.1134/S001249662001007X
- 2018Pharmacological Aspects of Neuro-Immune Interactions
Tarasov VV, Kudryashov NV, Chubarev VN, et al. · Current pharmaceutical design
PMID 28875850 · doi 10.2174/1381612823666170829135115
Show 2 more publicationsShow fewer
- 2017Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats
Medvedeva EV, Dmitrieva VG, Limborska SA, et al. · Molecular genetics and genomics : MGG
PMID 28255762 · doi 10.1007/s00438-017-1297-1
- 2014The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
Medvedeva EV, Dmitrieva VG, Povarova OV, et al. · BMC genomics
PMID 24661604 · doi 10.1186/1471-2164-15-228
Products are supplied strictly for laboratory and research use. They are not for human or veterinary consumption, and have not been evaluated by the U.S. Food and Drug Administration for the diagnosis, treatment, cure, or prevention of any condition.