Elements DNA
Published research · Cognitive

Selank

Tuftsin analogue with a stabilising Pro-Gly-Pro tail, studied in GABAergic models.

8 papers · 2017–2022 · 5 journals

What the research explores

Selank appears in preclinical literature spanning neurochemistry and immunology, which reflects the dual origin of its sequence.

Areas of study:

  • GABAergic signalling, including reported changes in GABA-A receptor subunit gene expression in rodent brain
  • Monoamine turnover, particularly serotonin metabolism in animal models
  • Inhibition of enkephalin-degrading enzymes in plasma
  • Interleukin expression, following from the immunological background of tuftsin
  • Behavioural models in rodents, including elevated plus maze paradigms

These are research questions examined in animals and cell systems. As with Semax, independent replication outside the originating groups is limited. Selank is supplied as a laboratory research material.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2022

    1. Long-term Survival of Adhesively Luted Post-endodontic Restorations

      Bruhnke M, Wierichs RJ, von Stein-Lausnitz M, et al.

      Journal of endodontics

      PMID 35183596doi 10.1016/j.joen.2022.02.006

    2. Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats

      Konstantinopolsky MA, Chernyakova IV, Kolik LG

      Bulletin of experimental biology and medicine

      PMID 36322304doi 10.1007/s10517-022-05624-x

  2. 2020

    1. Functional Connectomic Approach to Studying Selank and Semax Effects

      Panikratova YR, Lebedeva IS, Sokolov OY, et al.

      Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections

      PMID 32342318doi 10.1134/S001249662001007X

  3. 2019

    1. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

      Kolik LG, Nadorova AV, Antipova TA, et al.

      Bulletin of experimental biology and medicine

      PMID 31625062doi 10.1007/s10517-019-04588-9

    2. Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress

      Fomenko EV, Bobyntsev II, Ivanov AV, et al.

      Bulletin of experimental biology and medicine

      PMID 31243679doi 10.1007/s10517-019-04512-1

    3. Isoselenocarbonyl complexes

      Cade IA , Hill AF , McQueen CMA

      Dalton transactions (Cambridge, England : 2003)

      PMID 30657145doi 10.1039/c8dt04947e

  4. 2017

    1. Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons

      Povarov IS, Kondratenko RV, Derevyagin VI, et al.

      Bulletin of experimental biology and medicine

      PMID 28361410doi 10.1007/s10517-017-3676-3

    2. Tuftsin - Properties and Analogs

      Siebert A, Gensicka-Kowalewska M, Cholewinski G, et al.

      Current medicinal chemistry

      PMID 28745220doi 10.2174/0929867324666170725140826

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For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA