Pinealon

Pinealon is a tripeptide — glutamic acid, aspartic acid, arginine — belonging to the class of short peptide bioregulators developed at the St. Petersburg Institute of Bioregulation and Gerontology. Compounds in that class are unusually small, typically two to four residues, and the working hypothesis behind them is that sequences this short can interact directly with DNA and chromatin rather than with cell-surface receptors.

Whether that hypothesis holds is an open research question, and the supporting literature is narrow and concentrated in a small number of groups. The material ships as a lyophilised powder in a sealed vial, reconstituted in the laboratory with bacteriostatic water.

Pinealon is examined within the short-peptide-bioregulator literature, a body of work that is small and concentrated in a handful of research groups.

Areas of study:

• Binding interactions with DNA and histone proteins in cell-free systems
• Neuronal cell survival in culture under experimental oxidative stress
• Expression of markers associated with programmed cell death in cultured cells
• Rodent behavioural studies following prenatal hypoxia models

Independent replication outside the originating institutions is limited, and this is best read as an early-stage literature rather than a settled one. Pinealon is supplied strictly as a research material with no approved application in humans.