Elements DNA
Published research · Longevity

MOTS-c

Mitochondrial-derived 16-amino-acid peptide encoded in mitochondrial DNA

7 papers · 2016–2025 · 6 journals

What the research explores

Research on MOTS-c centres on mitonuclear communication, meaning how a mitochondrially encoded peptide influences events in the nucleus. Published work explores:

  • Interaction with the folate-methionine cycle and the accumulation of AICAR
  • AMPK pathway activation and downstream metabolic enzyme regulation in cell models
  • Nuclear translocation of the peptide under metabolic stress conditions
  • Sequence conservation and expression of mitochondrial-derived peptides across species
  • Analytical detection of short mitochondrially encoded peptides in tissue

These describe published lines of scientific inquiry. Elements DNA makes no claim about metabolic, performance or health outcomes and supplies this compound strictly for in vitro and preclinical laboratory work.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2025

    1. MOTS-c-modified functional self-assembly peptide hydrogels enhance the activity of nucleus pulposus-derived mesenchymal stem cells of intervertebral disc degeneration

      Lin Y, Yang RY, Li J, et al.

      Materials today. Bio

      PMID 40510834doi 10.1016/j.mtbio.2025.101872

    2. MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes

      Li X, Zhan F, Qiu G, et al.

      Redox biology

      PMID 40403491doi 10.1016/j.redox.2025.103681

    3. MOTS-c mimics remote ischemic preconditioning in protecting against lung ischemia-reperfusion injury by alleviating endothelial barrier dysfunction

      Wang DD, Xu B, Sun JJ, et al.

      Free radical biology & medicine

      PMID 39827923doi 10.1016/j.freeradbiomed.2025.01.016

  2. 2024

    1. MOTS-c modulates skeletal muscle function by directly binding and activating CK2

      Kumagai H, Kim SJ, Miller B, et al.

      iScience

      PMID 39559755doi 10.1016/j.isci.2024.111212

    2. Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection

      Lin C, Luo L, Xun Z, et al.

      Gut

      PMID 37788894doi 10.1136/gutjnl-2023-330389

  3. 2023

    1. MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria

      Zhang Z, Chen D, Du K, et al.

      Mitochondrion

      PMID 37307934doi 10.1016/j.mito.2023.06.002

  4. 2016

    1. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

      Lee C, Kim KH, Cohen P

      Free radical biology & medicine

      PMID 27216708doi 10.1016/j.freeradbiomed.2016.05.015

More research in longevity

For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA