Elements DNA
Published research · Tissue

TB-500

Thymosin Beta-4

Synthetic counterpart of thymosin β-4, studied in cell-migration models.

7 papers · 1985–2019 · 6 journals

What the research explores

Thymosin β-4 and its synthetic counterparts are studied for their role in cytoskeletal regulation, which places them across a wide span of preclinical repair literature.

Areas of investigation include:

  • G-actin sequestration, and the assembly and disassembly of actin filaments
  • Cell migration in culture, including endothelial and epithelial model systems
  • Angiogenesis and vessel formation in animal models
  • Dermal and corneal wound-model research
  • Cardiac tissue models following experimental injury

All of the above is preclinical. The peptide is supplied for laboratory research and has no approved application in humans.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2019

    1. Tβ4-Ac-SDKP pathway: Any relevance for the cardiovascular system?

      Kassem KM, Vaid S, Peng H, et al.

      Canadian journal of physiology and pharmacology

      PMID 30854877doi 10.1139/cjpp-2018-0570

  2. 2018

    1. Thymosin beta 4 and the eye: the journey from bench to bedside

      Sosne G

      Expert opinion on biological therapy

      PMID 30063853doi 10.1080/14712598.2018.1486818

  3. 2016

    1. Thymosin β4 Promotes Dermal Healing

      Kleinman HK, Sosne G

      Vitamins and hormones

      PMID 27450738doi 10.1016/bs.vh.2016.04.005

  4. 2007

    1. beta-Thymosins

      Hannappel E

      Annals of the New York Academy of Sciences

      PMID 17468232doi 10.1196/annals.1415.018

    2. The beta-thymosin enigma

      Sun HQ, Yin HL

      Annals of the New York Academy of Sciences

      PMID 17495248doi 10.1196/annals.1415.021

  5. 2001

    1. Actin dynamics

      Pollard TD, Blanchoin L, Mullins RD

      Journal of cell science

      PMID 11112680doi 10.1242/jcs.114.1.3

  6. 1985

    1. Thymosin beta 4

      Low TL, Goldstein AL

      Methods in enzymology

      PMID 4088087doi 10.1016/s0076-6879(85)16018-0

More research in tissue

For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA