DihexA
Angiotensin IV analogue, studied in hepatocyte growth factor signalling research.
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- Every batch tested by an independent laboratory — identity by HPLC and mass spec.
- Dispatched on business days once payment has cleared. Free shipping over $100 — flat $10 otherwise.
- Discreet packaging, tracked and insured on every shipment.
For laboratory and research use only · Not for human consumption
- Certificate
- Record in preparation
- Class
- Angiotensin IV analogue (peptidomimetic)
- Form
- Dry powder, sealed vial
- Storage
- Cool, dry and out of direct light
What we test, every batch.
Each production lot of DihexA is analysed by an independent laboratory before it ships. Its certificate is not in our published archive yet — we won't link one we don't hold.
Certificates we have publishedThe panel, every batch
- Identity
- HPLC + mass spec
- Purity
- HPLC · figure on the batch COA
- Net peptide content
- HPLC
- Heavy metals
- ICP-MS
- Sterility
- PCR
- Endotoxin
- USP <85>
What it is
DihexA is a synthetic analogue of angiotensin IV, the fragment sitting at the far end of the renin–angiotensin cascade. It is not a conventional peptide. The molecule is a short peptidomimetic, capped at both ends with non-natural groups so that it resists the peptidases that clear angiotensin IV within minutes.
That modification is the entire design intent: angiotensin IV is interesting to neuroscience and close to useless as a research tool at its natural stability. DihexA was constructed in academic work at Washington State University to hold the pharmacophore while surviving long enough to be studied. It ships as a dry powder in a sealed vial.
What the research explores
DihexA appears in a narrow preclinical literature centred on hepatocyte growth factor and its receptor.
Areas of study:
- Interaction with hepatocyte growth factor and c-Met receptor signalling
- Dendritic spine formation and synaptogenesis in cultured hippocampal neurons
- Rodent cognition models, including water-maze paradigms following experimental cholinergic lesion
- Blood–brain-barrier permeability, a pharmacokinetic property that was a stated design goal
The c-Met pathway is also implicated in tumour biology, and that overlap remains an open question in the literature rather than a resolved one. DihexA is an investigational compound with no approved use in any species and is supplied for laboratory research only.
Questions
Why is no molecular weight listed?
Our internal record carries a figure we have not been able to reconcile against the published structure of DihexA, so we have left it off rather than print a number we cannot stand behind. The batch certificate of analysis states the analytical result for the material you receive.
Is DihexA a peptide?
Not in the ordinary sense. It is a peptidomimetic: a short backbone capped at both ends with non-natural groups, designed to hold the shape of an angiotensin IV fragment while resisting the enzymes that would otherwise clear it.
What does the certificate of analysis cover?
Identity confirmation and purity by HPLC for the specific batch in your vial, with the batch identifier matching the label. We hold one for every batch and will send the PDF on request.
How should it be stored?
Sealed, cool, dry and out of direct light. Unlike the lyophilised peptides in this catalogue, DihexA is not a straightforward candidate for reconstitution in bacteriostatic water, so solvent selection is left to the receiving laboratory.
Literature
8 publications · 2005–2024
Peer-reviewed publications indexed on PubMed that discuss DihexA. Listed for reference only — inclusion is not a claim about this product or its effects.
- 2024Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats
Wells RG, Azzam AF, Hiller AL, et al. · Journal of Huntington's disease
PMID 38489193 · doi 10.3233/JHD-231507
- 2022Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy
Pan T, Wang N, Zhang J, et al. · Stem cell research & therapy
PMID 35410439 · doi 10.1186/s13287-022-02831-1
- 2018Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies
Ho JK, Nation DA · Neuroscience and biobehavioral reviews
PMID 29733881 · doi 10.1016/j.neubiorev.2018.05.005
- 2016Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells
Mathapati S, Siller R, Impellizzeri AA, et al. · Current protocols in stem cell biology
PMID 27532814 · doi 10.1002/cpsc.13
- 2015Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure
Uribe PM, Kawas LH, Harding JW, et al. · Frontiers in cellular neuroscience
PMID 25674052 · doi 10.3389/fncel.2015.00003
Show 3 more publicationsShow fewer
- 2014The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
Benoist CC, Kawas LH, Zhu M, et al. · The Journal of pharmacology and experimental therapeutics
PMID 25187433 · doi 10.1124/jpet.114.218735
- 2013Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents
McCoy AT, Benoist CC, Wright JW, et al. · The Journal of pharmacology and experimental therapeutics
PMID 23055539 · doi 10.1124/jpet.112.199497
- 2005Studies on the subcellular localization of the porphycene CPO
Kessel D, Conley M, Vicente MG, et al. · Photochemistry and photobiology
PMID 15745423 · doi 10.1562/2004-12-16-RA-403
Products are supplied strictly for laboratory and research use. They are not for human or veterinary consumption, and have not been evaluated by the U.S. Food and Drug Administration for the diagnosis, treatment, cure, or prevention of any condition.