TB-500

TB-500 is the designation used in research supply for synthetic peptide material corresponding to thymosin β-4, a small actin-binding peptide present across mammalian tissues and among the more abundant peptides found in cytoplasm. Its defining structural feature is an actin-binding motif that allows it to sequester monomeric G-actin, which is why the molecule appears wherever cytoskeletal dynamics are under study.

The material is produced synthetically rather than extracted from tissue. It ships lyophilised — a dry powder in a sealed vial, reconstituted in the laboratory with bacteriostatic water — with a molecular weight of 4963.4 g/mol on the batch record.

Thymosin β-4 and its synthetic counterparts are studied for their role in cytoskeletal regulation, which places them across a wide span of preclinical repair literature.

Areas of investigation include:

• G-actin sequestration, and the assembly and disassembly of actin filaments
• Cell migration in culture, including endothelial and epithelial model systems
• Angiogenesis and vessel formation in animal models
• Dermal and corneal wound-model research
• Cardiac tissue models following experimental injury

All of the above is preclinical. The peptide is supplied for laboratory research and has no approved application in humans.