Elements DNA
Published research · Sleep

DSIP

Delta Sleep-Inducing Peptide

Nonapeptide isolated from cerebral blood dialysate, studied in delta-EEG research.

8 papers · 1984–2021 · 8 journals

What the research explores

DSIP is studied as an open question. The literature is decades old, thin and inconsistent, and that is a large part of why the peptide continues to attract attention.

Areas that have been examined:

  • Electroencephalographic delta-wave activity in animal models, the original observation
  • Circadian and chronobiological rhythm studies
  • Corticotropin and somatotropin release in rodent endocrine models
  • Stress-response and thermoregulation endpoints in animals
  • Attempts to identify a binding site, none of which have produced a confirmed receptor

No consistent effect has been established across this work. DSIP has no approved application in humans and is supplied strictly as a research material.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2021

    1. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

      Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER, et al.

      Molecules (Basel, Switzerland)

      PMID 34500605doi 10.3390/molecules26175173

  2. 2015

    1. Peptides and the blood-brain barrier

      Banks WA

      Peptides

      PMID 25805003doi 10.1016/j.peptides.2015.03.010

  3. 2014

    1. Delta-sleep inducing peptide entrapment in the charged macroporous matrices

      Sukhanova TV, Artyukhov AA, Gurevich YM, et al.

      Materials science & engineering. C, Materials for biological applications

      PMID 25063142doi 10.1016/j.msec.2014.05.059

  4. 2006

    1. Delta sleep-inducing peptide (DSIP): a still unresolved riddle

      Kovalzon VM, Strekalova TV

      Journal of neurochemistry

      PMID 16539679doi 10.1111/j.1471-4159.2006.03693.x

  5. 2001

    1. Delta sleep-inducing peptide

      Pollard BJ, Pomfrett CJ

      European journal of anaesthesiology

      PMID 11437870doi 10.1046/j.1365-2346.2001.00917.x

  6. 1992

    1. Neuropeptides in the amphibian brain

      Andersen AC, Tonon MC, Pelletier G, et al.

      International review of cytology

      PMID 1280630doi 10.1016/s0074-7696(08)61588-0

    2. HPA-related CSF neuropeptides in suicide attempters

      Träskman-Bendz L, Ekman R, Regnéll G, et al.

      European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

      PMID 1378770doi 10.1016/0924-977x(92)90018-4

  7. 1984

    1. Delta-sleep-inducing peptide (DSIP): a review

      Graf MV, Kastin AJ

      Neuroscience and biobehavioral reviews

      PMID 6145137doi 10.1016/0149-7634(84)90022-8

More research in sleep

For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA