Elements DNA
Published research · Metabolic

Cagrilintide

Long-acting amylin analogue studied at the calcitonin and amylin receptor complexes

7 papers · 2021–2026 · 6 journals

What the research explores

Cagrilintide is studied as a probe of the amylin receptor family, a set of heterodimers formed when the calcitonin receptor pairs with receptor activity-modifying proteins (RAMP1-3) to give the AMY1-3 subtypes. Published preclinical work explores:

  • Binding affinity and selectivity across AMY1-3 and the calcitonin receptor
  • Downstream cAMP accumulation and receptor desensitisation kinetics in cell lines
  • How acylation alters plasma half-life and the duration of receptor engagement in rodent models
  • Signalling behaviour when amylin and incretin receptor pathways are activated together in preclinical models

These describe directions of investigation reported in the scientific literature. Elements DNA makes no representation about outcomes in humans and supplies this material for in vitro and preclinical laboratory work only.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2026

    1. Structural and mechanistic insights into dual activation of cagrilintide in amylin and calcitonin receptors

      Gu YM, Yuan QN, Li X, et al.

      Acta pharmacologica Sinica

      PMID 40847076doi 10.1038/s41401-025-01635-2

    2. A cross-species atlas of the dorsal vagal complex reveals neural mediators of the effects of cagrilintide on energy balance

      Ludwig MQ, Coester B, Gordian D, et al.

      Nature metabolism

      PMID 42260119doi 10.1038/s42255-026-01539-3

    3. Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism

      Lewis JE, Montaner M, Nuzzaci D, et al.

      Nature metabolism

      PMID 42498824doi 10.1038/s42255-026-01575-z

  2. 2025

    1. Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors

      Cao J, Belousoff MJ, Johnson RM, et al.

      Nature communications

      PMID 40204768doi 10.1038/s41467-025-58680-y

    2. Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3

      Carvas AO, Leuthardt A, Kulka P, et al.

      EBioMedicine

      PMID 40609154doi 10.1016/j.ebiom.2025.105836

  3. 2022

    1. Creating the amylin story

      Lutz TA

      Appetite

      PMID 35183619doi 10.1016/j.appet.2022.105965

  4. 2021

    1. Development of Cagrilintide, a Long-Acting Amylin Analogue

      Kruse T, Hansen JL, Dahl K, et al.

      Journal of medicinal chemistry

      PMID 34288673doi 10.1021/acs.jmedchem.1c00565

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For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA