ARA-290

ARA-290 is a short synthetic peptide taken from helix B of erythropoietin — the face of the protein that contacts the innate repair receptor rather than the classical EPO receptor homodimer. Because it reproduces only that region, it does not carry the erythropoietic activity of the parent hormone. That separation is the whole point of the molecule in an experiment: it lets a study probe one signaling arm of erythropoietin without the other.

Made by solid-phase synthesis and shipped as a 10 mg lyophilized powder in a sealed glass vial, kept dry until a laboratory reconstitutes it. Supplied for laboratory research use only.

The peptide exists to dissect a receptor question, and its literature follows that. Areas of study include:

• Innate repair receptor engagement — the heteromeric complex of the EPO receptor and the beta common receptor (CD131), and how a helix B mimetic binds it.
• Dissociation of signaling arms — comparing tissue-directed signaling against the haematopoietic response driven by the EPO receptor homodimer.
• Inflammatory cell signaling in vitro, using the peptide as a receptor-selective tool.
• Structure-activity relationships of helix B mimetics — which residues of the eleven are load-bearing.
• Peptide stability and clearance kinetics relative to the full-length hormone.

Supplied as a characterized reagent. We make no claim about outcomes in any organism.