Elements DNA
Published research · Skin

MT-2

Melanotan II

Cyclic alpha-MSH analogue studied in melanocortin receptor and melanogenesis research

8 papers · 2003–2024 · 8 journals

What the research explores

This compound appears in cell-biology literature as a melanocortin receptor probe. Studied areas include:

  • Agonist activity at MC1R and cross-reactivity with other melanocortin receptor subtypes
  • cAMP-dependent activation of microphthalmia-associated transcription factor (MITF) in cultured melanocytes
  • Tyrosinase expression and eumelanin synthesis measured in melanocyte and melanoma cell lines
  • Comparison of the cyclic analogue against linear alpha-MSH for potency and degradation resistance
  • Receptor structure-function work using conformationally constrained peptide ligands

These bullets describe pathways under laboratory investigation in cell-culture systems. They are not claims about effects in people. Elements DNA supplies this material for in vitro and preclinical research only.

References

A reference list, not evidence. Inclusion means a paper discusses the compound — not that it supports any use, and not that it describes this product.

  1. 2024

    1. Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner

      Ford CL, McDonough AA, Horie K, et al.

      Neuropharmacology

      PMID 38253222doi 10.1016/j.neuropharm.2024.109848

  2. 2022

    1. CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists

      Tomassi S, Dimmito MP, Cai M, et al.

      Journal of medicinal chemistry

      PMID 35188390doi 10.1021/acs.jmedchem.1c01848

    2. Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons

      Islam MT, Rumpf F, Tsuno Y, et al.

      Current biology : CB

      PMID 35907397doi 10.1016/j.cub.2022.07.020

  3. 2019

    1. Eruptive Melanocytic Nevi: A Review

      Burian EA, Jemec GBE

      American journal of clinical dermatology

      PMID 31119650doi 10.1007/s40257-019-00444-8

  4. 2012

    1. Melanotan-associated melanoma in situ

      Ong S, Bowling J

      The Australasian journal of dermatology

      PMID 22724573doi 10.1111/j.1440-0960.2012.00915.x

    2. [Melanotan]

      Mahiques-Santos L

      Actas dermo-sifiliograficas

      PMID 22051769doi 10.1016/j.ad.2011.08.002

  5. 2009

    1. Use of melanotan I and II in the general population

      Evans-Brown M, Dawson RT, Chandler M, et al.

      BMJ (Clinical research ed.)

      PMID 19224885doi 10.1136/bmj.b566

  6. 2003

    1. Having it all

      Gura T

      Science (New York, N.Y.)

      PMID 12574617doi 10.1126/science.299.5608.850

For laboratory and research use only · Not for human or veterinary consumption · Not evaluated by the FDA